Research Summaries

POND studies

Studying Social Deficits Across ASD, ADHD, and OCD

Children use social skills to communicate and interact with others. Poor social skills, known as social deficits, include limited social communication and interaction skills, among others. Social deficits are a defining characteristic of some neurodevelopmental disorders. The researchers in this study investigated the underlying biology of social deficits in children with different neurodevelopmental disorders. This study included various disorders because of the increasing recognition that different neurodevelopmental disorders have similar symptoms and characteristics.

Heterogeneity in genetic tests marketed for Autism Spectrum Disorders

Autism spectrum disorder (ASD) is diagnosed by experienced professionals who look at a child’s behaviour and development. What causes ASD is complex, but there is increasing evidence that genes play an important role. To investigate the genetic contribution to a child’s ASD diagnosis, clinicians can order genetic tests marketed for ASD. These tests look for genetic differences in a list of genes that are thought to be associated with ASD.

Children with ADHD, ASD and OCD show similar changes to connections within their brain

Children with attention deficit hyperactivity disorder, obsessive compulsive disorder and autism spectrum disorder develop connections between areas in their brain differently. Changes to brain connections show similarities across these neurodevelopmental disorders and are linked to children’s independent living skills.

TAOK2 gene causes autism-related changes to brain development and behaviour

The TAOK2 gene is involved the development of the brain and its cells. Specifically, changes to this gene affect how brain cells communicate with each other. This study reveals that TAOK2 is a risk gene for neurodevelopmental disorders.

The Oxytocin Receptor and Social Abilities Across Neurodevelopmental Disorders

The two most common variants of the oxytocin receptor were associated with greater severity of social skills deficits in children with Autism Spectrum Disorder, while the same variants were associated with reduced levels of social skills deficits in children with attention-deficit hyperactivity disorder.

Genetic Variants Affect Brain Connections in Some People with ASD

Researchers found DIXDC1, a gene that affects the way brain cells can communicate with each other, is “turned off” in some people with Autism Spectrum Disorder, affecting memory and social communication.

Children with Neurodevelopmental Disorders Share Problems Identifying Emotions

Children and youth with neurodevelopmental disorders showed problems recognizing the emotional and mental states in others, but to varying degrees. These difficulties seemed to be related to the severity of their social communication deficits.

Studies involving POND researchers

Using epigenetics to Differentiate Between Two Similar Neurodevelopmental Disorders and Identify Shared Biology

Developmental Pathways of Preschool Children with ASD

Medication Management of Behavioural Disorders in Autism

Diagnostic Symptoms and Problem Behaviours in Children with Autism Spectrum Disorder

Studies involving other Canadian researchers

Thriving in Youth with Autism Spectrum Disorder and Intellectual Disability

The Impact on their Families of Children with Special Needs

Resilience in Families of Children With Special Needs

Family Care for Children with Disabilities

Cognitive Profile of Children and Adolescents with Fragile X Syndrome

Other research summaries

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