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Research Summaries

POND studies

TAOK2 gene causes autism-related changes to brain development and behaviour

The TAOK2 gene is involved the development of the brain and its cells. Specifically, changes to this gene affect how brain cells communicate with each other. This study reveals that TAOK2 is a risk gene for neurodevelopmental disorders.

The Oxytocin Receptor and Social Abilities Across Neurodevelopmental Disorders

The two most common variants of the oxytocin receptor were associated with greater severity of social skills deficits in children with Autism Spectrum Disorder, while the same variants were associated with reduced levels of social skills deficits in children with attention-deficit hyperactivity disorder.

Genetic Variants Affect Brain Connections in Some People with ASD

Researchers found DIXDC1, a gene that affects the way brain cells can communicate with each other, is “turned off” in some people with Autism Spectrum Disorder, affecting memory and social communication.

Children with Neurodevelopmental Disorders Share Problems Identifying Emotions

Children and youth with neurodevelopmental disorders showed problems recognizing the emotional and mental states in others, but to varying degrees. These difficulties seemed to be related to the severity of their social communication deficits.

Studies involving POND researchers

Developmental Pathways of Preschool Children with ASD

Medication Management of Behavioural Disorders in Autism

Diagnostic Symptoms and Problem Behaviours in Children with Autism Spectrum Disorder

Studies involving other Canadian researchers

Thriving in Youth with Autism Spectrum Disorder and Intellectual Disability

The Impact on their Families of Children with Special Needs

Resilience in Families of Children With Special Needs

Family Care for Children with Disabilities

Cognitive Profile of Children and Adolescents with Fragile X Syndrome

Other research summaries

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POND Network: Alana Iaboni
Holland Bloorview Kids Rehabilitation Hospital: Susan Day Fragiadakis
The Hospital for Sick Children: Kira Sklar
Lawson Health Research Institute/Western University: Ahsan Ahmad
McMaster University: Mike Chalupka
Queen’s University: - Melissa Hudson
Holland Bloorview Kids Rehabilitation Hospital: Ontario Clinical Trials Network - Lisa Genore
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The POND Network is an Integrated Discovery Program carried out in partnership with the Ontario Brain Institute.