Top
Content

Research Publications

Genetics

  1. Uddin M, Unda BK, Kwan V, Holzapfel NT, White SH, Chalil L, Woodbury-Smith M, Ho KS, Harward E, Murtaza N, Dave B, Pellecchia G, D’Abate L, Nalpathamkalam T, Lamoureux S, Wei J, Speevak M, Stavropoulos J, Hope KJ, Doble BW, Nielsen J, Wassman ER, Scherer SW, Singh KK (2018). OTUD7A regulates neurodevelopmental phenotypes in the 15q13. 3 microdeletion syndrome. The American Journal of Human Genetics, 102(2), 278-295. [Go to article]
  2. Yuen RKC, Merico D, Cao H, Pellecchia G, Alipanahi B, Thiruvahindrapuram B, Tong X, Sun Y, Cao D, Zhang T, Wu X, Jin X, Zhou Z, Liu X, Nalpathamkalam T, Walker S, Howe JL, Wang Z, MacDonald JR, Chan AJS, D’Abate L, Deneault E, Siu MT, Tammimies K, Uddin M, Zarrei M, Wang M, Li Y, Wang J, Wang J, Yang H, Bookman M, Bingham J, Gross SS, Loy D, Pletcher M, Marshall CR, Anagnostou E, Zwaigenbaum L, Weksberg R, Fernandez BA, Roberts W, Szatmari P, Glazer D, Frey BJ, Ring RH, Xu X, & Scherer SW (2016). Genome-wide characteristics of de novo mutations in autism. NPJ genomic medicine1, 16027. [Go to article]
  3. Yuen RK, Thiruvahindrapuram B, Merico D, Walker S, Tammimies K, Hoang N, Chrysler C, Nalpathamkalam T, Pellecchia G, Liu Y, Gazzellone MJ, D’Abate L, Deneault E, Howe JL, Liu RS, Thompson A, Zarrei M, Uddin M, Marshall CR, Ring RH, Zwaigenbaum L, Ray PN, Weksberg R, Carter MT, Fernandez BA, Roberts W, Szatmari P, & Scherer SW (2015). Whole-genome sequencing of quartet families with autism spectrum disorder. Nature medicine21(2), 185-191. [Go to abstract]

Behaviour/Cognition

  1. Sarabadani S, Schudlo LC, Samadani AA, & Kushki A (2018). Physiological Detection of Affective States in Children with Autism Spectrum Disorder. IEEE Transactions on Affective Computing. [Go to abstract]
  2. Baribeau DA, Dupuis A, Paton TA, Scherer SW, Schachar RJ, Arnold PD, Szatmari P, Nicolson R, Georgiades S, Crosbie J, Brian J, Iaboni A, Lerch J & Anagnostou E (2017). Oxytocin receptor polymorphisms are differentially associated with social abilities across neurodevelopmental disorders. Scientific reports7(1), 11618. [Go to POND research summary] [Go to article]
  3. Saghir H, Dupuis A, Chau T, & Kushki A (2017). Atypical autonomic nervous system complexity accompanies social cognition task performance in ASD. Research in Autism Spectrum Disorders39, 54-62. [Go to abstract]
  4. Saghir H, Chau T, & Kushki A (2016). Clustering of time-evolving scaling dynamics in a complex signal. Physical Review E94(1), 012220. [Go to abstract]
  5. Baribeau DA, Dupuis A, Paton T, Doyle-Thomas KA, Iaboni A, Crosbie J, McGinn H, Arnold PD, Brian J, Kushki A, Nicolson R, Schachar RJ, Soreni N, Szatmari P, Anagnostou E. (2015). Examining and comparing social perception abilities across childhood onset neurodevelopmental disorders. Journal of the American Academy of Child & Adolescent Psychiatry54(6), 479-486. [Go to POND research summary] [Go to abstract]
  6. Chiu T, Anagnostou E, Brian J, Chau T, Kushki A. (2015). Specificity of Autonomic Arousal to Anxiety in Children with Autism Spectrum Disorder. Autism Research9(4), 491-501. [Go to abstract]
  7. Kushki A, Khan A, Brian J, & Anagnostou E (2015). A Kalman filtering framework for physiological detection of anxiety-related arousal in children with autism spectrum disorder. IEEE Transactions on Biomedical Engineering62(3), 990-1000. [Go to abstract]
  8. Panju S, Brian J, Anagnostou E, & Kushki A (2015). Atypical Sympathetic Arousal in Children with Autism Spectrum Disorder and its Association with Anxiety Symptomatology. Molecular autism6(1), 64. [Go to article]
  9. Kushki A, Brian J, Dupuis A, & Anagnostou E (2014). Functional Autonomic Nervous System Profile in Children with autism spectrum disorder. Molecular Autism5(1), 39. [Go to article]

Epigenetics

  1. Butcher DT, Cytrynbaum C, Turinsky AL, Siu MT, Inbar-Feigenberg M, Mendoza-Londono R, Chitayat D, Walker S, Machado J, Caluseriu O, Dupuis L, Grafodatskaya D, Reardon W, Gilbert-Dussardier B, Verloes A, Bilan F, Milunsky JM, Basran R, Papsin B, Stockley TL, Scherer SW, Choufani S, Brudno M, & Weksberg R (2017). CHARGE and Kabuki syndromes: gene-specific DNA methylation signatures identify epigenetic mechanisms linking these clinically overlapping conditions. The American Journal of Human Genetics100(5), 773-788. [Go to article]
  2. Choufani S, Cytrynbaum C, Chung BHY, Turinsky AL, Grafodatskaya D, Chen YA, Cohen ASA, Dupuis L, Butcher DT, Siu MT, Luk HM, Lo IFM, Lam STS, Caluseriu O, Stavropoulos DJ, Reardon W, Mendoza-Londono R, Brudno M, Gibson WT, Chitayat D, & Weksberg R (2015). NSD1 mutations generate a genome-wide DNA methylation signature. Nature communications6, 10207. [Go to article]
  3. Fairbrother LC, Cytrynbaum C, Boutis P, Buiting K, Rosanna Weksberg, & Williams C (2015). Mild Angelman syndrome phenotype due to a mosaic methylation imprinting defect. American Journal of Medical Genetics Part A167(7), 1565-1569. [Go to abstract]
  4. Melamed N, Choufani S, Wilkins-Haug LE, Koren G, & Weksberg R (2015). Comparison of genome-wide and gene-specific DNA methylation between ART and naturally conceived pregnancies. Epigenetics10(6), 474-483. [Go to article]
  5. Shugar AL, Shapiro JM, Cytrynbaum C, Hedges S, Weksberg R, & Fishman L (2015). An increased prevalence of thyroid disease in children with 22q11.2 deletion syndrome.  American Journal of Medical Genetics Part A167(7), 1560-1564. [Go to abstract]
  6. Strong E, Butcher DT, Singhania R, Mervis CB, Morris CA, De Carvalho D, Weksberg R, & Osborne LR (2015). Symmetrical dose-dependent DNA methylation profiles in children with deletion or duplication of chromosome 7q11.23. The American Journal of Human Genetics97(2), 216-227. [Go to article]

Imaging

  1. Mogadam A, Keller AE, Taylor MJ, Lerch JP, Anagnostou E, & Pang EW (2018). Mental flexibility: An MEG investigation in typically developing children. Brain and cognition120, 58-66. [Go to article]
  2. Ameis SH, Lerch JP, Taylor MJ, Lee W, Viviano J, Pipitone J, Nazeri A, Croarkin P, Voineskos A, Lai M-C, Crosbie J, Brian J, Soreni N, Schachar R, Szatmari P, Arnold PD, Anagnostou E (2016). A diffusion tensor imaging study in children with ADHD, ASD, OCD and matched controls: Distinct and non-distinct white matter disruption and dimensional brain-behavior relationships. American Journal of Psychiatry, 173(12), 1213-1222. [Go to article]
  3. Pang EW, Valica T, MacDonald M, Taylor MJ, Brian J, Lerch JP, & Anagnostou E (2016). Abnormal brain dynamics underlie speech production in children with autism spectrum disorder. Autism Research9(2), 249-261. [Go to article]
  4. Sussman D, Leung RC, Vogan VM, Lee W, Trelle S, Lin SY, Cassel DB, Chakravarty MM, Lerch JP, Anagnostou E, Taylor MJ (2015). The Autism Puzzle: Diffuse but not pervasive neuroanatomical features in children with ASD. NeuroImage: Clinical8, 170-179. [Go to article]
  5. Friedel M, van Eede MC, Pipitone J, Chakravarty MM, & Lerch JP (2014). Pydpiper: a flexible toolkit for constructing novel registration pipelines. Frontiers in neuroinformatics8, 67. [Go to article]

Immune

  1. Foster JA, Bienenstock J, Forsythe P, & Kunze WA (2017). Lactobacillus rhamnosus strain JB-1 reverses restraint stress-induced gut dysmotility. Neurogastroenterology & Motility29(1). [Go to abstract]
  2. West C, Wu RY, Wong A, Stanisz AM, Yan R, Min KK, Pasyk M, McVey Neufeld KA, Karamat MI, Foster JA (2017). Targeting the microbiome for mental health: Hype or hope? Biol Psych: 82:456-457. [Go to abstract]
  3. Bharwani A, Mian MF, Foster JA, Surrette MG, Bienenstock J, & Forsythe P (2016). Structural & functional consequences of chronic psychosocial stress on the microbiome & host. Psychoneuroendocrinology, 63, 217-227. [Go to abstract]
  4. Foster JA, Lyte M, Meyer E, & Cryan JF (2016). Gut microbiota and brain function: an evolving field in neuroscience. International Journal of Neuropsychopharmacology19(5). [Go to article]
  5. Luna RA & Foster JA (2015). Gut-brain axis: Diet microbiota interactions and implications for modulation of anxiety and depression. Current opinion in biotechnology32, 35-41. [Go to abstract]
  6. Zhou L, & Foster JA (2015). Psychobiotics and the gut-brain axis: in the pursuit of happiness. Neuropsychiatric disease and treatment11, 715. [Go to article]

Mouse and Cell Models

  1. Aujnarain AB, Luo OD, Taylor N, Lai JKY, & Foster JA (2018). Effects of exercise and enrichment on behaviour in CD-1 mice. Behav Brain Res. 342:43-50. [Go to abstract]
  2. Lai JKY, Doering LC, & Foster JA (2016). Developmental expression of neuroligins and neurexins in Fragile X mice. Journal of Comparative Neurology524(4), 807-828. [Go to abstract]
  3. Lai JKY, Lerch JP, Doering LC, Foster JA, & Ellegood J (2016). Regional brain volumes changes in adult male FMR1-KO mouse on the FVB strain. Neuroscience318, 12-21. [Go to abstract]
  4. Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JKY, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, Tam E, Osborne LR, Kouser M, Espinosa-Becerra F, Xuan Z, Powell CM, Raznahan A, Robins DM, Nakai N, Nakatani J, Takumi T, van Eede MC, Kerr TM, Muller C, Blakely RD, Veenstra-VanderWeele J, Henkelman RM, Lerch JP. (2015). Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity. Mol Psychiatry 20(1):118–25. [Go to abstract]
  5. Ellegood, J., & Crawley, J. N. (2015). Behavioral and neuroanatomical phenotypes in mouse models of autism. Neurotherapeutics12(3), 521-533. [Go to article]
  6. Ellegood J, Nakai N, Nakatani J, Henkelman M, Takumi T, & Lerch J (2015). Neuroanatomical Phenotypes Are Consistent With Autism-Like Behavioral Phenotypes in the 15q11-13 Duplication Mouse Model. Autism Research8(5), 545-555. [Go to abstract]
  7. Rilett, KC, Friedel M, Ellegood J, MacKenzie RN, Lerch JP, & Foster JA (2015). Loss of T cells influences sex differences in behavior and brain structure. Brain, Behavior, and Immunity. Brain, behavior, and immunity46, 249-260. [Go to abstract]
  8. Ellegood J, Markx S, Lerch JP, Steadman PE, Genç C, Provenzano F, Kushner SA, Henkelman RM, Karayiorgou M, Gogos JA (2014). Neuroanatomical phenotypes in a mouse model of the 22q11.2 microdeletion. Molecular psychiatry19(1), 99. [Go to abstract]
  9. Rilett, KC, & Foster JA (2014). T Lymphocytes and Anxiety: A Review of Clinical and Animal Studies. Ann Depress Anxiety1(7), 1034. [Go to article]
  10. Lai JKY, Sobala-Drozdowski M, L. Zhou, Doering LC, Faure PA, & Foster JA (2013). Temporal and spectral differences in ultrasonic vocalization in fmr1-/- mice during postnatal development. Behavioural brain research259, 119-130. [Go to abstract]
  11. Portmann T, Yang M, Mao R, Panagiotakos G, Ellegood J, Dolen G, Bader PL, Grueter BA, Goold C, Fisher E, Clifford K, Rengarajan P, Kalikhman D, Loureiro D, Saw NL, Zhengqui Z, Miller MA, Lerch JP, Henkelman RM, Shamloo M, Malenka RC, Crawley JN, & Dolmetsch RE (2014). Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome. Cell reports7(4), 1077-1092. [Go to article]
  12. Steadman PE, Ellegood J, Szulc KU, Turnbull DH, Joyner AL, Henkelman RM, & Lerch JP (2014). Genetic effects on cerebellar structure across mouse models of autism using a magnetic resonance imaging atlas. Autism research7(1), 124-137. [Go to article]
  13. Ellegood J, Babineau BA, Henkelman RM, Lerch JP, Crawley JN (2013). Neuroanatomical analysis of the BTBR mouse model of autism using magnetic resonance imaging and diffusion tensor imaging. Neuroimage70, 288-300. [Go to abstract]
  14. Ellegood J, Henkelman RM, Lerch JP (2012). Neuroanatomical Assessment of the Integrin β3 Mouse Model Related to Autism and the Serotonin System Using High Resolution MRI. Frontiers in psychiatry3, 37. [Go to article]
  15. Ellegood J, Lerch JP, Henkelman RM (2011). Brain abnormalities in a Neuroligin3 R451C knockin mouse model associated with autism. Autism Research4(5), 368-376. [Go to abstract]
  16. Horev G, Ellegood J, Lerch JP, Son YE, Muthuswamy L, Vogel H, Krieger AM, Buja A, Henkelman RM, Wigler M, Mills AA (2011). Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism. Proceedings of the National Academy of Sciences108(41), 17076-17081. [Go to article]

iPS Cells

  1. Richter M, Murtaza N, Scharrenberg R, White SH, Johanns O, Walker S, Yuen RKC, Schwanke B, Bedürftig B, Henis M, Scharf S, Kraus V, Dörk R, Hellmann J, Lindenmaier Z, Ellegood J, Hartung H, Kwan V, Sedlacik J, Fiehler J, Schweizer M, Lerch JP, Hanganu-Opatz IL, Morellini F, Scherer SW, Singh KK, de Anda FC (2018). Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling. Molecular psychiatry, 1. [Go to POND research summary] [Go to article]
  2. Djuric U, Rodrigues DC, Batruch I, Ellis J, Shannon P & Diamandis P (2017). Spatiotemporal proteomic profiling of human cerebral development. Molecular & Cellular Proteomics16(9), 1548-1562. [Go to article]
  3. Kwan V, Hung CL, White S, Hoszapfel NT, Walker S, Murtaza N, Unda BK, Yuen RKC, Habing K, Milsom C, Hope K, Truant R, Scherer SW, & Singh KK (2016). DIXDC1 phosphorylation and control of dendritic morphology is impaired by rare genetic variants. Cell reports17(7), 1892-1904. [Go to POND research summary] [Go to article]
  4. Djuric U, Cheung AY, Zhang W, Mok RS, Lai W, Piekna A, Hendry JA, Ross J, Pasceri P, Kim DS, Salter MW, & Ellis J. (2015). MECP2e1 isoform mutation affects the form and function of neurons derived from Rett syndrome patient iPS cells. Neurobiology of disease76, 37-45. [Go to article]
  5. Kim D, Ross PJ, Zaslavsky K, & Ellis J (2014). Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD. Frontiers in cellular neuroscience8, 109. [Go to article]

Contact Us
POND Network: Alana Iaboni
Holland Bloorview Kids Rehabilitation Hospital: Susan Day Fragiadakis
The Hospital for Sick Children: Kira Sklar
Lawson Health Research Institute/Western University: Ahsan Ahmad
McMaster University: Mike Chalupka
Queen’s University: - Melissa Hudson
Holland Bloorview Kids Rehabilitation Hospital: Ontario Clinical Trials Network - Lisa Genore
Sponsors

The POND Network is an Integrated Discovery Program carried out in partnership with the Ontario Brain Institute.